Composition for smokeless tobacco and orally dissolvable film-type smokeless tobacco comprising same

ABSTRACT

The present invention relates to a composition for smokeless tobacco and orally dissolvable film-type smokeless tobacco comprising same. More specifically, the present invention relates to a composition for orally dissolvable film-type smokeless tobacco, which is capable of improving the intraoral uptake rate, moldability, and taste of nicotine while reducing harmfulness to the human body, orally dissolvable film-type smokeless tobacco comprising same, and a manufacturing method thereof.

FIELD

The present disclosure relates to a composition for smokeless tobaccoand orally dissolvable film-type smokeless tobacco containing the same.More specifically, the present disclosure relates to a composition fororally dissolvable film-type smokeless tobacco, which is capable ofimproving an intraoral intake rate of nicotine, moldability, andacceptability while lowering harmfulness to a human body, orallydissolvable film-type smokeless tobacco containing the same, and amethod for manufacturing the same.

DESCRIPTION OF RELATED ART

A development of smokeless tobacco is becoming more active as aseriousness of a damage caused by secondhand smoking is widely known andbecause of changes in a social environment of reducing smoking places.However, traditional smokeless tobacco, such as wet snuff and the like,is considered wet and dirty, so that use of the traditional smokelesstobacco is negative.

Accordingly, recently, as a kind of the smokeless tobacco, products in amesh structure, a film form, or a sheet form that may dissolve in auser's mouth to release nicotine have been developed.

However, the conventional smokeless tobacco contains a number ofsubstances, such as tar in addition to the nicotine, harmful to a humanbody with a main component of tobacco particles, and is not completelydissolved, so that precipitate remains. In addition, in a manufacture ofthe conventional smokeless tobacco, a high temperature treatment processat a temperature equal to or higher than 100° C. had to be undergone todissolve the tobacco particles. Furthermore, the conventional smokelesstobacco contains a tobacco component in a high dose, which causes a verybitter taste and a low acceptability. In addition, the conventionalsmokeless tobacco is formed by being molded into a laminated body shapeor by extruding a non-aqueous composition or melting the non-aqueouscomposition at a high temperature, so that a manufacturing process iscomplicated, a process cost is increased, and a productivity is low.

In one example, in general, an oral dissolving film (ODF) refers to aformulation that is taken by being attached to an oral cavity, such as atop face of a tongue, oral mucosa, a bottom face of the tongue, and thelike, and being dissolved, which is a concept that includes an ediblefilm in which a raw material, such as starch, that is not harmful to thehuman body and is well soluble in water and a substance that isbeneficial to the human body are mixed with each other. Such oraldissolving film has an advantage of being able to be taken without thewater and being convenient to carry.

The edible film is manufactured by adding a plasticizer, an emulsifier,a sweeting agent, an acidulant, a flavor, and other additives to a baseof a water-soluble polymer, such as pullulan, sodium alginate, pectin,gelatin, carrageenan, xanthan gum, locust bean gum, and the like.

The conventional oral dissolving film is stored by coating a liquidedible raw material on a base film paper, then drying the base filmpaper, and then rolling the base film paper. Alternatively, theconventional oral dissolving film is manufactured by transporting therolled base film paper to a packaging machine, then slitting the basefilm paper, then cutting the base film paper into a size considering afilm surface area, and then inserting each cut base film paper into eachpackaging material to be packaged and sealed. Therefore, theconventional oral dissolving film is unreasonable in that there are alarge number of manufacturing processes and a semi-finished productstock is generated as being stored in the roll shape. Thus, theconventional oral dissolving film has a problem that additional hygienemanagement is required as well as a cost is increased due toproductivity decrease and stock burden.

As a background technology of the present disclosure, Korean PatentApplication Publication No. 10-2012-0087937 discloses a wet smokelesstobacco product for oral use having a gel coating of a net structure anda method for manufacturing the same.

Throughout the present disclosure, a number of patent documents arereferenced and citations thereof are indicated. An entirety of thedisclosed content of the cited patent document is inserted as areference in the present disclosure, so that the level of the technicalfield to which the present disclosure belongs and the content of thepresent disclosure are more clearly described.

DISCLOSURE Technical Purposes

A purpose of the present disclosure is to provide a composition forsmokeless tobacco capable of lowering harmfulness to a human body andimproving moldability and acceptability of film-type smokeless tobacco.

Another purpose of the present disclosure is to provide orallydissolvable film-type smokeless tobacco with a reduced intraoraldisintegration time and an improved intraoral intake rate of nicotine.

Another purpose of the present disclosure is to provide a method formanufacturing orally dissolvable film-type smokeless tobacco that has asimple process and excellent productivity.

Other objects and advantages of the present disclosure will become moreapparent by the following detailed description, claims, and drawings.

Technical Solutions

In a first aspect of the present disclosure, a composition for smokelesstobacco containing a nicotine activator of 0.01 to 4 parts by weight, abinder of 40 to 80 parts by weight, and a plasticizer of 2 to 10 partsby weight is provided.

In one implementation of the first aspect, the nicotine activator may benicotine oil and have a purity equal to or above 99%.

In one implementation of the first aspect, the binder may behydroxypropylmethylcellulose or hydroxypropylcellulose.

In one implementation of the first aspect, the binder may be containedin 40 to 60 parts by weight.

In one implementation of the first aspect, the composition may furthercontain water as a solvent.

In one implementation of the first aspect, viscosity may be 15,000±5,000cps.

In one implementation of the first aspect, the composition may furthercontain a flavor, and at least one of a surfactant, a sweeting agent,and a coloring agent.

In a second aspect of the present disclosure, provided is a smokelesstobacco including a first region formed by coating the composition forthe smokeless tobacco of one of claims 1 to 7 in a film form, whereinthe smokeless tobacco is in an orally dissolvable film-type.

In one implementation of the second aspect, the smokeless tobacco mayfurther include a second region formed by coating a flavor composition,a functional food composition, a beauty treatment composition, apharmaceutical composition, or a mixture thereof in the film form to beadjacent to the first region.

In one implementation of the second aspect, at least one of thecomposition for the smokeless tobacco, the flavor composition, thefunctional food composition, the beauty treatment composition, thepharmaceutical composition, and the mixture thereof may further containa coloring agent.

In one implementation of the second aspect, the smokeless tobacco may bedisintegrated within 5 minutes after being placed in an oral cavity.

In a third aspect of the present disclosure, provided is a method formanufacturing orally dissolvable film-type smokeless tobacco includingdischarging the composition for the smokeless tobacco of one of claims 1to 7 in a single dose through a first nozzle such that the dischargedcomposition is coated on a first region of a packaging material, therebyforming a first region coating, discharging a flavor composition, afunctional food composition, a beauty treatment composition, apharmaceutical composition, or a mixture thereof in a single dosethrough a second nozzle such that the discharged composition is coatedon a second region of the packaging material adjacent to the firstregion, thereby forming a second region coating, and drying the firstregion coating and the second region coating.

In one implementation of the third aspect, the drying of the firstregion and the second region may be performed at a temperature in arange from 50 to 90° C.

Technical Effects

According to an embodiment, the composition for the smokeless tobaccomay lower the harmfulness to the human body and improve the moldabilityand the acceptability of the film-type smokeless tobacco.

According to an embodiment, the orally dissolvable film-type smokelesstobacco may reduce the intraoral disintegration time and improve theintraoral intake rate of the nicotine.

According to an embodiment, the method for manufacturing the orallydissolvable film-type smokeless tobacco has the simple process and theexcellent productivity.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a view showing a packaging state of orally dissolvablefilm-type smokeless tobacco including a first region according to anembodiment.

FIG. 2 is a schematic perspective view of orally dissolvable film-typesmokeless tobacco including a first region and a second region accordingto an embodiment.

FIG. 3 is a view showing a packaging state of orally dissolvablefilm-type smokeless tobacco including a first region and a second regionaccording to an embodiment.

FIG. 4 is a graph showing a result of a test of nicotine elution by timeof orally dissolvable film-type smokeless tobaccos according to anexample and a comparative example.

DETAILED DESCRIPTIONS

Purposes, specific advantages, and novel features of the presentdisclosure will become more apparent from the following detaileddescription and embodiments associated with the accompanying drawings.

Prior to this, terms or words used in the specification and claimsshould not be interpreted in a conventional and dictionary meaning, andshould be interpreted as a meaning and concept consistent with thetechnical idea of the present disclosure based on the principle that theinventor is able to properly define the concept of terms to describe theinvention thereof in the best way.

In the present specification, when a component such as a layer, aportion, or a substrate is described as being “on”, “connected to”, or“coupled to” another component, it may be directly “on”, “connected to”,or “coupled to” another element, or one or more intervening componentsmay be present. In contrast, when a component is described as being“directly on”, “directly connected to”, or “directly coupled to” anothercomponent, no other component may be interposed between the twocomponents.

The terminology used herein is for the purpose of describing particularembodiments only and is not intended to limit the present disclosure. Asused herein, the singular forms “a” and “an” are intended to include theplural forms as well, unless the context clearly indicates otherwise.

It will be further understood that the terms “comprises”, “comprising”,“includes”, and “including” when used in this specification, specify thepresence of the stated features, integers, operations, components,parts, and/or combinations thereof, but do not preclude the presence oraddition of one or more other features, integers, operations,components, parts, and/or combinations thereof.

In the present specification, when a certain portion “includes” acertain component, it means that other components may be furtherincluded rather than excluding other components unless otherwisespecified. In addition, throughout the specification, the term “on”means to be positioned on or beneath the target portion, and does notnecessarily mean to be positioned at an upper side with respect to thedirection of gravity.

The present disclosure is intended to illustrate specific embodiments inthe drawings and to describe the specific embodiments in detail in thedetailed description as various transformations may be applied andvarious embodiments may be applied. However, this is not intended tolimit the present disclosure to the specific embodiments, and it is tobe understood as including all modifications, equivalents, andalternatives included in the spirit and scope of the present disclosure.In describing the present disclosure, when it is determined that adetailed description of a related known technology may obscure the gistof the present disclosure, a detailed description thereof will beomitted.

Hereinafter, embodiments of the present disclosure will be described indetail with reference to the accompanying drawings. In the descriptionwith reference to the accompanying drawings, the same or correspondingcomponents are assigned the same reference numerals, and redundantdescriptions thereof will be omitted.

Composition for Smokeless Tobacco

According to an embodiment, a composition for smokeless tobacco containsa nicotine activator of 0.01 to 4 parts by weight; a binder of 40 to 80parts by weight; and a plasticizer of 2 to 10 parts by weight.

The composition for the smokeless tobacco contains the nicotineactivator in a low dose to reduce harmfulness to a human body, and atthe same time, improve acceptability and intraoral disintegration degreeof film-type smokeless tobacco.

The nicotine activator is a main component of the composition for thesmokeless tobacco, which may be nicotine or a nicotine derivative. Thenicotine derivative may be a nicotine salt (tartaric acid, citric acid,and the like) or a nicotine complex. The nicotine activator is nicotineoil, which may be suitable to have a purity equal to or higher than 99%,but is not limited thereto. Because the composition for the smokelesstobacco does not contain tobacco particles, components, such as tar andthe like, harmful to the human body are excluded, thereby reducing theharmfulness of the smokeless tobacco to the human body.

The nicotine activator may be contained in 0.01 to 4 parts by weightbased on a solid weight of the composition for the smokeless tobacco.Although not limited thereto, when the nicotine activator of less than0.01 parts by weight is contained based on the solid weight of thecomposition for the smokeless tobacco, it is difficult to meet needs ofa user who needs the nicotine. Further, when the nicotine activator iscontained in excess of 4 parts by weight, a very bitter taste may beproduced, the acceptability may be reduced, and intraoral disintegrationtime may be lengthened. The harmfulness to the human body may be reducedby containing the nicotine activator in a low dose. In addition, evenwhen the nicotine activator is contained in the low dose, an absorptionrate of the nicotine may become relatively high compared to a high dosebecause of a reaction of the body for maintaining a nicotine content ina blood at a level equal to or above a certain level.

The nicotine activator may be contained, based on the solid weight ofthe composition for the smokeless tobacco, in 0.01 to 4 parts by weight,in 0.01 to 3.5 parts by weight, in 0.01 to 2.5 parts by weight, in 0.01to 1.0 parts by weight, in 0.01 to 0.5 parts by weight, in 0.05 to 4parts by weight, in 0.05 to 3.5 parts by weight, in 0.05 to 2.5 parts byweight, in 0.05 to 1.0 parts by weight, in 0.05 to 0.5 parts by weight,in 0.1 to 4 parts by weight, in 0.1 to 3.5 parts by weight, in 0.1 to2.5 parts by weight, in 0.1 to 1.0 parts by weight, and in 0.1 to 0.5parts by weight. The content of the nicotine activator may be suitably0.01 to 2.5 parts by weight, more suitably 0.01 to 1.0 parts by weight,and even more suitably 0.01 to 0.5 parts by weight, but may not belimited thereto.

The binder is decomposed by saliva in an oral cavity to release thenicotine into the oral cavity, and allows the nicotine activator to bemolded in a film form. The binder may be hydroxypropylmethylcellulose orhydroxypropylcellulose. The hydroxypropylmethylcellulose may be suitablein terms of moldability, the acceptability, and the intraoraldisintegration time when the smokeless tobacco is manufactured as thefilm, but the present disclosure may not be limited thereto. Therefore,because the composition for the smokeless tobacco does not contain ametharylic acid ethyl acrylate copolymer, problems of lowering of theacceptability and prolonged intraoral disintegration time resulted fromthe metharylic acid ethyl acrylate may be solved. In addition, unlike inthe prior art, the smokeless tobacco may be rapidly disintegrated in theoral cavity even though the smokeless tobacco does not contain analkaline buffer.

The binder may be contained in 40 to 80 parts by weight based on thesolid weight of the composition for the smokeless tobacco. When thebinder is contained in less than 40 parts by weight of the compositionfor the smokeless tobacco, the moldability may be rapidly deterioratedwhen the smokeless tobacco is manufactured as the film. In addition,when the binder is contained in excess of 80 parts by weight, themoldability, the acceptability, and the intraoral disintegration degreemay be deteriorated when the smokeless tobacco is manufactured as thefilm, but the present disclosure may not be limited thereto. The bindermay be contained, based on the solid weight of the composition for thesmokeless tobacco, in 40 to 80 parts by weight, in 40 to 70 parts byweight, in 40 to 60 parts by weight, in 40 to 50 parts by weight, in 50to 80 parts by weight, in 50 to 70 parts by weight, in 50 to 60 parts byweight, in 60 to 80 parts by weight, and in 60 to 70 parts by weight.The content of the binder may be suitably 40 to 70 parts by weight, andmore suitably 40 to 60 parts by weight, but may not be limited thereto.

At least one type of the plasticizer may be contained in the compositionfor the smokeless tobacco. The plasticizer may include glycerin,propylene glycol, ethylene glycol, polyethylene glycol, sorbitol,xylitol, maltitol, erythritol, tributhyl citrate, triethyl citrate,triacetin, and glycerol triacetate, but may not be limited thereto.

The plasticizer may be contained in 2 to 10 parts by weight based on thesolid weight of the composition for the smokeless tobacco. When theplasticizer is contained in less than 2 parts by weight based on thesolid weight of the composition for the smokeless tobacco, themoldability may be rapidly deteriorated when the smokeless tobacco ismanufactured as the film. In addition, when the plasticizer is containedin excess of 10 parts by weight, the moldability, the acceptability, andthe intraoral disintegration degree may be deteriorated when thesmokeless tobacco is manufactured as the film, but the presentdisclosure may not be limited thereto. The plasticizer may be contained,based on the solid weight of the composition for the smokeless tobacco,in 2 to 10 parts by weight, in 2 to 7 parts by weight, in 2 to 5 partsby weight, or in 2 to 3 parts by weight. The content of the plasticizermay be suitably 2 to 7 parts by weight, and more suitably 2 to 5 partsby weight, but may not be limited thereto.

The composition for the smokeless tobacco may contain water as asolvent. Using the water as the solvent instead of an organic solventsuch as ethanol and the like may be suitable in terms of themoldability, the acceptability, and the shortening of the disintegrationtime when the smokeless tobacco is manufactured as the film. Purifiedwater may be used as the water, and may be contained in 180 to 250 partsby weight based on 100 parts by weight of a solid content, but thepresent disclosure may not be limited thereto.

The composition for the smokeless tobacco may have a viscosity of15,000±5,000 cps. When the viscosity of the composition for thesmokeless tobacco is out of the above range, the moldability may belowered when the smokeless tobacco is manufactured as the film, but thepresent disclosure may not be limited thereto.

The composition for the smokeless tobacco may further contain at leastone of a flavor, a surfactant, a sweeting agent, and a coloring agent.These components may improve the acceptability and the moldability ofthe smokeless tobacco.

The flavor may improve the acceptability of the smokeless tobacco as aflavoring agent. Although not limited thereto, the flavor may includenatural and artificial flavors, and may include, for example,peppermint, spearmint, winter green, menthol, cinnamon, chocolate,vanillin, licorice, clove, anise, sandalwood, geranium, rose oil,vanilla, lemon oil, cassia, fennel, ginger, ethyl acetate, isoamylacetate, propyl isobutylate, isobutyl butyrate, ethyl butyrate, ethylvalerate, benzyl formate, limonene, cymene, pinene, linalol, geraniol,citronellol, citral, orange oil, coriander oil, borneol, fruit extract,and the like. Although not limited thereto, the flavor may be containedin 0.50 to 5 parts by weight based on the solid weight of thecomposition for the smokeless tobacco. In an embodiment, L-menthol,peppermint flavor, and peppermint oil were used as the flavors.

There is no particular limitation as long as the surfactant is able tobe used as an edible emulsifier. Although not limited thereto, thesurfactant includes glycerin fatty acid ester, sucrose fatty acid ester,sorbitan fatty acid ester, propylene glycol fatty acid ester, soybeanphospholipid, stearyl lactylate, sorbitan oleate, sodium lauryl sulfate,hydrogenated polyoxyethylene castor oil, polyoxyethylene octylphenylether, and the like. Although not limited thereto, the surfactant may becontained in 1 to 10 parts by weight based on the solid weight of thecomposition for the smokeless tobacco. In an embodiment, polysorbate 80was used as the plasticizer.

The sweeting agent may include both natural and artificial sweetingagents. Although not limited thereto, the sweeting agent includes awater-soluble sweeting agent such as monosaccharide, disaccharide andpolysaccharide (i.e., xylose, ribose, sucrose, maltose, fructose,glucose, maltose, mannose), sucralose, aspartame, sodium saccharin,stevioside, rebaudioside, and thaumatin. Although not limited thereto,the sweeting agent may be contained in 0.001 to 1.0 parts by weightbased on the solid weight of the composition for the smokeless tobacco.In an embodiment, the sucralose, the xylitol, the stevioside, and thelike were used as the sweeting agents.

There is no particular limitation as long as the coloring agent is ableto be used as a food coloring agent. The coloring agent may include bothnatural and artificial coloring agents. As limited thereto, the coloringagent may include green No. 3, red No. 2, red No. 3, blue No. 1, blueNo. 2, yellow No. 4, and yellow No. 5 as tar-based coloring agents. Inaddition, β-carotene, water-soluble annatto, copper sulfate, ferricoxide, caramel, copper and sodium iron chlorophyllin, titanium oxide,and the like may be included as non-tar-based coloring agents. Althoughnot limited thereto, the coloring agent may be contained in 0.0001 to1.0 parts by weight based on the solid weight of the composition for thesmokeless tobacco. In an embodiment, the blue No. 1 was used as thecoloring agent.

In addition, the composition for the smokeless tobacco may additionallycontain at least one type of known diluents.

Orally Dissolvable Film-Type Smokeless Tobacco

FIG. 1 is a view showing a packaging state of orally dissolvablefilm-type smokeless tobacco including a first region according to anembodiment. FIG. 2 is a schematic perspective view of orally dissolvablefilm-type smokeless tobacco including a first region and a second regionaccording to an embodiment. In addition, FIG. 3 is a view showing apackaging state of orally dissolvable film-type smokeless tobaccoincluding a first region and a second region according to an embodiment.

As shown in FIG. 1, the orally dissolvable film-type smokeless tobaccomay be formed as orally dissolvable film-type smokeless tobacco 1composed of only a first region. The first region may be formed bycoating the composition for the smokeless tobacco containing 0.01 to 4parts by weight of the nicotine activator; 40 to 80 parts by weight ofthe binder; 2 to 10 parts by weight of the plasticizer; the flavor, thesurfactant, the coloring agent, the sweeting agent, and the diluent. Areference numeral 22 of FIG. 1 denotes a lower packaging material of thesmokeless cigarette 1, a reference numeral 24 denotes an upper packagingmaterial of the smokeless cigarette 1, and a numeral 26 denotes anadhesive.

In addition, as shown in FIG. 2, the smokeless tobacco may be formed asorally dissolvable film-type smokeless tobacco 10 including both a firstregion 12 and a second region 14. The orally dissolvable film-typesmokeless tobacco 10 includes the first region 12 formed by coating thecomposition for the smokeless tobacco in the film form; and the secondregion 14 formed by coating a flavor composition, a functional foodcomposition, a beauty treatment composition, a pharmaceuticalcomposition, or a mixture thereof in the film form to be adjacent to thefirst region.

That is, the orally dissolvable film-type smokeless tobacco 10 includingboth the first region 12 and the second region 14 may be formed of thesmokeless tobacco composition containing the nicotine activator as themain component in the first region 12, and the second region 14 may beformed of the flavor composition, the functional food composition, thebeauty treatment composition, the pharmaceutical composition, or themixture thereof, excluding the nicotine activator.

When the second region 14 formed of the flavor composition is furtherincluded, the acceptability of the smokeless tobacco may be improved.Although not limited thereto, the flavor composition may contain theplasticizer, the surfactant, the flavor, the coloring agent, thesweeting agent, and the diluent. There is no particular limitation aslong as the plasticizer, the surfactant, the flavor, the coloring agent,the sweeting agent, and the diluent are able to improve theacceptability and are suitable for the coating process. A person skilledin the art may appropriately select and use a known material for theflavor composition.

In addition, when the second region 14 formed of the functional foodcomposition, the beauty treatment composition, or the pharmaceuticalcomposition is further included, the harmfulness to the human bodyresulted from absorption of the nicotine may be reduced or eliminated.There is no particular limitation as long as the functional foodcomposition, the beauty treatment composition, or the pharmaceuticalcomposition is beneficial to the human body and is suitable for thecoating process. A person skilled in the art may appropriately selectand use a known functional food composition, such as red ginseng forenhancing immunity with beneficial functionality, vitamin, a nutritionalsupplement, food good for a bronchial tube and/or a lung. Although notlimited thereto, the food good for the bronchial tube and/or the lungmay include schisandra, quince, loofah, radish, ginseng, bellflower,pumpkin, pear, persimmon, citron, and the like. The food good for thebronchial tube and/or the lung may help to prevent or alleviate cough,bronchitis, pneumonia, and the like resulted from the absorption of thenicotine. In addition, the beauty treatment or the pharmaceuticalcomposition includes a dental whitening material, a mouthwash, ananticaries compound, an anti-tartar compound, an antioxidant, ananti-inflammatory agent, a pain reliever, an antihistaminic agent, atopical anesthetic, an antibacterial compound, a germicide, anantibiotic, an antiasthmatic agent, and the like.

Furthermore, the smokeless tobacco 10 may further include one or moreadditional regions adjacent to the first region 12 or the second region14. Thus, for example, a smokeless tobacco that is divided into a secondregion and a third region with different functions may be formed. Onlythe first region of the smokeless tobacco may be ingested as neededbased on the above component, or the second region and/or the thirdregion may be ingested based on the acceptability.

At least one of the composition for the smokeless tobacco, the flavorcomposition, the functional food composition, the beauty treatmentcomposition, the pharmaceutical composition, and the mixture thereof mayfurther contain the coloring agent. When the coloring agent is containedas described above, the first region 12 and the second region 14 may bedistinguished from each other, so that the first region 12 and thesecond region 14 of the smokeless tobacco may be selectively ingested.That is, only the first region 12 of the smokeless tobacco may beingested as needed, or the first region 12 and only a portion of thesecond region 14 may be ingested based on the acceptability. Inaddition, when the coloring agent is contained as described above,aesthetics of the smokeless tobacco may be improved.

The smokeless tobacco may be in a form of a rectangular or ellipticalfilm to properly adjust a disintegration speed while being placed in theoral cavity of the user.

The smokeless tobacco may have a surface area of 400 to 800 mm² and athickness of 50 to 100 μm, but may not be limited thereto. When thesurface area and the thickness of the smokeless tobacco are respectivelyout of the above ranges, the intraoral disintegration speed and theintraoral intake rate may be lowered.

The smokeless tobacco may have a moisture content of 3 to 5 parts byweight and a pH of 7 to 9, but may not be limited thereto.

The smokeless tobacco may be substantially completely disintegratedwithin 5 minutes after being placed in the oral cavity. It may beappropriate that the smokeless tobacco is substantially completelydisintegrated within 3 minutes after being placed into the oral cavity,and it may be more appropriate that the smokeless tobacco issubstantially completely disintegrated within 2 minutes, but the presentdisclosure may not be limited thereto. Therefore, the smokeless tobaccomay be immediately released so as to quickly meet needs of the user whoneeds the nicotine.

The smokeless tobacco may be disintegrated within 5 minutes after beingplaced into the oral cavity and gradually release the nicotine untilabout 50 minutes has elapsed to induce sustained release. Accordingly,the smokeless tobacco may satisfy both rapid nicotine craving relief andcontinuous nicotine craving relief.

As described above, the orally dissolvable film-type smokeless tobaccomay use the composition for the smokeless tobacco containing thenicotine activator of the low dose, so that the absorption of thenicotine may be increased and the intraoral disintegration time may beshortened. In addition, because the smokeless tobacco is in the orallydissolvable film-type, the intraoral intake rate of the nicotine may beimproved. The orally dissolvable film-type smokeless tobacco rapidlydissolves in the oral cavity, so that the nicotine at a levelsubstantially equivalent to that of a high-dose smokeless tobaccoproduct may be absorbed through capillaries of oral mucosa. This isbecause, as described above, even though the nicotine activator iscontained in the low dose in the smokeless tobacco, the absorption ofthe nicotine may become relatively high because of a reaction of thebody for maintaining a nicotine content in a blood at a level equal toor above a certain level. In addition, as described above, the smokelesstobacco may satisfy both the rapid nicotine craving relief and thecontinuous nicotine craving relief

Method for Manufacturing Orally Dissolvable Film-Type Smokeless Tobacco

According to an embodiment, the method for manufacturing the orallydissolvable film-type smokeless tobacco includes forming the firstregion by discharging the composition for the smokeless tobacco in asingle dose through a first nozzle and coating the dischargedcomposition on a packaging material; discharging the flavor composition,the functional food composition, the beauty treatment composition, thepharmaceutical composition, or the mixture thereof in a single dosethrough a second nozzle and coating the same on the packaging materialto be adjacent to the first region to form the second region; and dryingthe first region and the second region.

The composition for the smokeless tobacco for forming the first regionmay be prepared, for example, by following processes.

First, the plasticizer and the surfactant are dissolved in purifiedwater in a first preparation tank.

The solution in which the plasticizer and the surfactant are dissolvedin the first preparation tank is homogenized by optionally adding theflavor, the sweeting agent, and the like thereto.

Then, the additional flavor (the L-menthol) that was dissolved inpurified water in a separate container is optionally added into thefirst preparation tank to homogenize the solution in the firstpreparation tank.

Then, the nicotine oil and the binder, which are the main components,and optionally the additional flavor are added into the firstpreparation tank to homogenize the solution in the first preparationtank.

The first preparation tank is depressurized, so that the composition forthe smokeless tobacco in the first preparation tank is cooled anddegassed to remove air bubbles.

In addition, the flavor composition for forming the second region may beprepared by following processes.

First, the plasticizer and the surfactant are dissolved in purifiedwater in a second preparation tank.

The solution in which the plasticizer and the surfactant are dissolvedin the second preparation tank is homogenized by optionally adding theflavor, the coloring agent, the sweeting agent, and the like.

Then, the flavor (the L-menthol) that was dissolved in purified water ina separate container is optionally added into the second preparationtank to homogenize the solution in the second preparation tank.

Then, the binder and optionally the additional flavor are added into thesecond preparation tank to homogenize the solution in the secondpreparation tank.

The second preparation tank is depressurized, so that the flavorcomposition in the second preparation tank is cooled and degassed toremove air bubbles.

The first region is formed by discharging the composition for thesmokeless tobacco prepared above in the single dose through the firstnozzle and coating the discharged composition on the packaging material.

Then, the second region is formed by discharging the flavor compositionprepared above in the single dose through the second nozzle and coatingthe discharged flavor composition on the packaging material to beadjacent to the first region.

FIG. 3 is a view showing a packaging state of the orally dissolvablefilm-type smokeless tobacco 10 including the first region 12 and thesecond region 14 according to an embodiment.

Referring to FIG. 3, as described above, the coating of the first region12 and the second region 14 does not require additional slitting andcutting processes because the compositions are discharged in the singledose. In addition, the coating of the first region 12 and the secondregion 14 is perform on a top face of the lower packaging material 22and dried, then covered with the upper packaging material 24 afterforeign matter inspection is performed, and then is sealed by theadhesive 26 on the packaging material, so that there is no need for aseparate storage step and productivity is improved.

The drying step may be performed at 50 to 90° C. As described above, theentire processes including the drying process are performed at atemperature lower than 100° C., so that process cost may be reducedcompared to conventional processes requiring a high-temperature meltingprocess.

The coating step of the first region 12 and the second region 14 may beperformed by an apparatus for manufacturing a multi-columnmulti-medicine oral dissolving film disclosed in Korean Patent No.10-1547219 of the present applicant.

In the method for manufacturing the orally dissolvable film-typesmokeless tobacco, the orally dissolvable film-type smokeless tobacco ismanufactured by being coated with predetermined size and thickness.Thus, the slitting and cutting processes are unnecessary, so that theprocesses are simple and the productivity is excellent. Further, in themethod for manufacturing the orally dissolvable film-type smokelesstobacco, the orally dissolvable film-type smokeless tobacco ismanufactured by being directly coated on the packaging material, so thatthere is no need to store the semi-finished product separately, therebysolving a problem associated with the semi-finished product storage. Inaddition, in the method for manufacturing the orally dissolvablefilm-type smokeless tobacco, the orally dissolvable film-type smokelesstobacco is formed in a single layer and formed in a single process anddoes not require the extrusion or the high-temperature melting process,so that the number of processes is small and the productivity isexcellent.

Hereinafter, the present disclosure will be described in more detailthrough examples.

EXAMPLES Example 1. Manufacture of Film-Type Smokeless Tobacco Based onNicotine Content

The glycerin as the plasticizer, the polysorbate 80 as the surfactant,the L-menthol as the flavor, the blue No. 1 as the coloring agent, thesucralose, the peppermint, the xylitol, and the stevia as the sweetingagent, and the diluent were added into the purified water, and stirredto be dissolved or dispersed, and then the solution was homogenizedusing a homogenizer (PL-HMZ30DN Poong Lim Tech).

The nicotine oil with various contents and thehydroxypropylmethylcellulose as the binder were added to the solution,and then the solution was homogenized again using the same homogenizer.After gas in the film preparation solution was removed under a vacuumcondition, the solution was coated on a pouch, which is the packagingmaterial, with a casting machine to have a size of 22 mm in width and 28mm in length, and a thickness of about 91 μm. Thereafter, the solutionwas dried for 10 to 20 minutes at a temperature in a range from 50 to90° C. to manufacture the film-type smokeless tobacco containing thenicotine.

Acceptability and disintegration degree of the film-type smokelesstobacco manufactured as described above were identified. Table 1 showsacceptability and a disintegration time based on a nicotine content ofeach of Example 1 and Comparative example 1. Comparative example 1-1used Niquitin®, a smoking aid product of GlaxoSmithKline, with anicotine content of 25 mg.

TABLE 1 Comparative Example Mixing Component 1-1 (

 Nicotine Example (%) Purpose Name 2.5 mg) 1-1 1-2 1-3 1-4 1-5 1-6 MainNicotine Oil (%) 0.017 0.084 0.168 0.502 0.833 0.653 Component mg 0.010.05 0.1 0.3 0.5 1.0 Binder Polymer 54.207 Plasticizer Plasticizer 2.50Surfactant Surfactant 3.762 Sweeting Sweeting 18.39

agent agent Flavor Flavor 19.962 Coloring Coloring 0.342 agent agentSupplementary Diluent

Material Taste test Effect of 1 4 4 4 4 4 4 taste masking DisintegrationDisintegration 1 4 4 4 4 3 3 Time time(sec) Comparative Example MixingComponent 1-1 (

 Nicotine Example (%) Comparative Example Purpose Name 2.5 mg) 1-7 1-81-2 1-3 1-4 Main Nicotine Oil (%) 2.459 3.252 4.032 7.752 10.526Component mg 1.5 2.0 2.5 5.0 7.0 Binder Polymer 54.207 PlasticizerPlasticizer 2.50 Surfactant Surfactant 3.762 Sweeting Sweeting 18.395Agent Agent Flavor Flavor 19.962 Coloring Coloring 0.342 Agent AgentSupplementary Diluent

Material Taste Test Effect of 1 4 3 2 2 1 taste masking DisintegrationDisintegration 1 3 3 3 3 3 Time time(sec) * taste masking value 1—poorRetention time of Bitter, burning effects: 61 min~ 2—not good Retentiontime of Bitter, burning effects: 21~60 min 3—not bad Retention time ofBitter, burning effects: 6~20 min 4—excellent Retention time of Bitter,burning effects: ~5 min * Disintegration time: This test is performedusing Disintegration tester 1—poor Retention time of ODF in sinker: 11min~ 2—not good Retention time of ODF in sinker: 8~10 min 3—not badRetention time of ODF in sinker: 2~5 min 4—excellent Retention time ofODF in sinker: ~1 min

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Example 2. Manufacture of Film-Type Smokeless Tobacco Based on BinderType

In the same manner as in Example 1, the plasticizer, the surfactant, theflavor, the coloring agent, the sweeting agent, and the diluent wereadded into the purified water, and stirred to be dissolved or dispersed,and then the solution was homogenized using the homogenizer (PL-HMZ30DNPoong Lim Tech).

The nicotine oil and various types of binders were applied and added tothe solution, and then the solution was homogenized again using the samehomogenizer. After gas in the film preparation solution was removedunder the vacuum condition, the solution was coated on the pouch withthe casting machine to have the size of 22 mm in width and 28 mm inlength, and the thickness of about 91 μm. Thereafter, the solution wasdried for 10 to 20 minutes at the temperature in the range from 50 to90° C. to manufacture the film-type smokeless tobacco containing thenicotine.

Moldability, acceptability, and disintegration degree of the film-typesmokeless tobacco manufactured as described above were identified. Table2 shows moldability, acceptability, and a disintegration time based onthe binder type of each of Example 2 and Comparative example 2.

TABLE 2 Comparative Mixing Component Example Example Example ExampleExample Purpose Name 2-1 2-2 2-1 2-3 2-4 Main Nicotine Oil (%) 0.165Component mg 0.1 Binder

50 40 40 Binder HydroxyPropyl- 10 10 Cellulose Binder HydroxyPropy- 4050 MethylCellulose Binder Methacrylic Acid 10 Ethyl Acrylate CopolymerPlasticizer Plasticizer 2.50 Surfactant Surfactant 3.762 SweetingSweeting 18.395 agent agent Flavor Flavor 19.082 Coloring Coloring 0.342agent agent Solvent Water

Solvent Ethanol

Film Filming Fair Fair Fair Good Good Formation Degree Taste Test Effectof 3 3 2 4 4 taste masking Disintegration Disintegration 4 4 3 4 4 Timetime(sec) Comparative Mixing Component Example Example Example ExampleExample Purpose Name 2-5 2-6 2-2 2-7 2-8 Main Nicotine Oil (%) 0.502Component mg 0.3 Binder

50 40 40 Binder HydroxyPropyl- 10 10 Cellulose Binder HydroxyPropy- 4050 MethylCellulose Binder Methacrylic Acid 10 Ethyl Acrylate CopolymerPlasticizer Plasticizer 2.50 Surfactant Surfactant 3.762 SweetingSweeting 18.395 agent agent Flavor Flavor 19.082 Coloring Coloring 0.342agent agent Solvent Water

Solvent Ethanol

Film Filming Fair Fair Fair Good Good Formation Degree Taste Test Effectof 3 3 2 4 4 taste masking Disintegration Disintegration 4 4 3 4 4 Timetime(sec) Comparative Mixing Component Example Example Example ExampleExample Purpose Name 2-9 2-10 2-3 2-11 2-12 Main Nicotine Oil (%) 0.833Component mg 0.5 Binder

50 40 40 Binder HydroxyPropyl- 10 10 Cellulose Binder HydroxyPropy- 4060 MethylCellulose Binder Methacrylic Acid 10 Ethyl Acrylate CopolymerPlasticizer Plasticizer 2.50 Surfactant Surfactant 3.762 SweetingSweeting 18.395 agent agent Flavor Flavor 19.962 Coloring Coloring 0.342agent agent Solvent Water

Solvent Ethanol

Film Filming Fair Fair Fair Good Good Formation Degree Taste Time Effectof 3 3 2 4 4 taste masking Disintegration Disintegration 4 4 3 4 4 Timetime(sec) Comparative Mixing Component Example Example Example ExampleExample Purpose Name 2-13 2-14 2-4 2-15 2-16 Main Nicotine Oil (%) 1.653Component mg 1.0 Binder

50 40 40 Binder HydroxyPropyl- 10 10 Cellulose Binder HydroxyPropy- 4060 MethylCellulose Binder Methacrylic Acid 10 Ethyl Acrylate CopolymerPlasticizer Plasticizer 2.50 Surfactant Surfactant 3.762 SweetingSweeting 18.395 agent agent Flavor Flavor 19.962 Coloring Coloring 0.342agent agent Solvent Water

Solvent Ethanol

Film Filming Fair Fair Fair Good Good Formation Degree Taste Time Effectof 3 3 2 4 4 taste masking Disintegration Disintegration 4 4 3 4 4 Timetime(sec) * taste masking value: 1—poor Retention time of Bitter,burning effects: 61 min~ 2—not good Retention time of Bitter, burningeffects: 21~60 min 3—not bad Retention time of Bitter, burning effects:6~20 min 4—excellent Retention time of Bitter, burning effects: ~5 min *Disintegration time: This test is performed using Disintegration tester1—poor Retention time of ODF in sinker: 11 min~ 2—not good Retentiontime of ODF in sinker: 8~10 min 3—not bad Retention time of ODF insinker: 2~5 min 4—excellent Retention time of ODF in sinker: ~1 min

indicates data missing or illegible when filed

Example 3. Manufacture of Film-Type Smokeless Tobacco Based on BinderContent

In the same manner as in Example 1, the plasticizer, the surfactant, theflavor, the coloring agent, the sweeting agent, and the diluent wereadded into the purified water, and stirred to be dissolved or dispersed,and then the solution was homogenized using the homogenizer (PL-HMZ30DNPoong Lim Tech).

The nicotine oil and the hydroxypropylmethylcellulose as the binder wereapplied and added to the solution in various weight ratios (w/w), andthen the solution was homogenized again using the same homogenizer.After gas in the film preparation solution was removed under the vacuumcondition, the solution was coated on the pouch with the casting machineto have the size of 22 mm in width and 28 mm in length, and thethickness of about 91 μm. Thereafter, the solution was dried for 10 to20 minutes at the temperature in the range from 50 to 90° C. tomanufacture the film-type smokeless tobacco containing the nicotine.

Moldability, acceptability, and disintegration degree of the film-typesmokeless tobacco manufactured as described above were identified. Table3 shows moldability, acceptability, and a disintegration time based oncomponents and contents of each of Example 3 and Comparative example 3.

TABLE 3 Comparative Comparative Comparative Comparative Mixing ComponentExample Example Example Example Example Example Purpose Name 3-1 3-1 3-23-3 3-2 3-3 3-4 3-5 3-6 3-4 Binder HydroxyPropyl- 20 40 60 80 90 20 4060 80 90 Cellulose(%) Main Nicotine Oil 0.1 mg 0.3 mg ComponentPlasticizer Plasticizer 2 mg Surfactant Surfactant 3 mg SweetingSweeting 10 mg agent agent Supplementary Diluent

Material Solvent Water 100 mg Film Filming Poor Good Good Fair Poor PoorGood Good Fair Poor Formation Degree Taste Test Effect of 4 4 4 3 2 4 44 3 2 taste masking Disintegration Disintegration 4 3 3 2 2 4 3 3 2 2Time time(sec) Comparative Comparative Comparative Comparative MixingComponent Example Example Example Example Example Example Purpose Name3-5 3-7 3-8 3-9 3-6 3-7 3-10 3-11 3-12 3-8 Binder HydroxyPropyl- 20 4060 80 90 20 40 60 80 90 Cellulose(%) Main Nicotine Oil 0.5 mg 1.0 mgComponent Plasticizer Plasticizer 2 mg Surfactant Surfactant 3 mgSweeting Sweeting 10 mg agent agent Supplementary Diluent

Material Solvent Water 100 mg Film Filming Poor Good Good Fair Poor PoorGood Good Fair Poor Formation Degree Taste Test Effect of 4 4 4 3 2 4 44 3 2 taste masking Disintegration Disintegration 4 3 3 2 2 4 3 3 2 2Time time(sec) * taste masking value: 1—poor Retention time of Bitter,burning effects: 61 min~ 2—not good Retention time of Bitter, burningeffects: 21~60 min 3—not bad Retention time of Bitter, burning effects:6~20 min 4—excellent Retention time of Bitter, burning effects: ~5 min *Disintegration time: This test is performed using Disintegration tester1—poor Retention time of ODF in sinker: 11 min~ 2—not good Retentiontime of ODF in sinker: 8~10 min 3—not bad Retention time of ODF insinker: 2~5 min 4—excellent Retention time of ODF in sinker: ~1 min

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Example 4. Manufacture of Parallel Coating Film-Type Smokeless TobaccoIncluding Nicotine-Containing Film and Flavor-Containing Film

First Preparation Tank—Preparing Smokeless Tobacco CompositionContaining Main Components

In the same manner as in Example 1, the plasticizer, the surfactant, thesweeting agent, and the diluent were added into the purified water, andstirred to be dissolved or dispersed, and then the solution washomogenized using the homogenizer (PL-HMZ30DN Poong Lim Tech).

The nicotine oil and the hydroxypropylmethylcellulose as the binder wereapplied and added to the solution in the various weight ratios (w/w),and then the solution was homogenized again using the same homogenizer.

Second Preparation Tank—Preparing Composition Containing Flavor andColoring Agent

In the same manner as in Example 1, the plasticizer, the surfactant, theflavor, the coloring agent, the sweeting agent, and the diluent wereadded into the purified water, and stirred to be dissolved or dispersed,and then the solution was homogenized using the homogenizer (PL-HMZ30DNPoong Lim Tech). The hydroxypropylmethylcellulose as the binder wasapplied and added to the solution in the weight ratio (w/w), and thenthe solution was homogenized again using the same homogenizer.

Gas in the film preparation solution was removed under the vacuumcondition. When the single dose of the nicotine oil is 0.5 mg, the firstregion and the second region were coated in parallel on the pouch withthe casting machine such that each of the first region and the secondregion has a size of 22 mm in width and 14 mm in length and a thicknessof about 91 μm. Thereafter, the first region and the second region weredried for 10 to 20 minutes at the temperature in the range from 50 to90° C. to manufacture the film-type smokeless tobacco containing thenicotine.

Moldability, acceptability, and disintegration degree of the film-typesmokeless tobacco manufactured as described above were identified. Table4 shows moldability, acceptability, and a disintegration time based oncomponents and contents of each of Examples 4-1 to 4-3 and Comparativeexample 4-1.

TABLE 4 Comparative Example Example 4-1 4-2 4-3 4-1 Mixing ComponentFirst Second First Second First Second First Second Purpose Name UnitRegion Region Region Region Region Region Region Region Main NicotineOil mg 0.5 — 0.5 — 0.5 — 0.5 — Component Binder HydroxyPropy- % 20 20 4040 60 60 80 80 MethylCellulose Plasticizer Plasticizer % 2.9 2.6 2.9 2.62.9 2.6 2.9 2.6 Surfactant Surfactant % 4.4 4.0 4.4 4.0 4.4 4.0 4.4 4.0Sweeting Sweeting % 20 20 20 20 20 20 20 20 agent agent Flavor Flavor %— 15 — 15 — 15 — 15 Coloring Coloring % — 1.0 — 1.0 — 1.0 — 1.0 agentagent Supplementary Diluent

Material Solvent Water 100 mg Film Filming Good Good Good Good Good GoodFair Fair Formation Degree Taste Test Effect of 4 4 4 4 4 4 4 4 tastemasking Disintegration Disintegration 3 3 3 3 3 3 2 2 Time time(sec) *taste masking value: 1—poor Retention time of Bitter, burning effects:61 min~ 2—not good Retention time of Bitter, burning effects: 21~60 min3—not bad Retention time of Bitter, burning effects: 6~20 min4—excellent Retention time of Bitter, burning effects: ~5 min *Disintegration time: This test is performed using Disintegration tester1—poor Retention time of ODF in sinker: 11 min~ 2—not good Retentiontime of ODF in sinker: 6~10 min 3—not bad Retention time of ODF insinker: 2~5 min 4—excellent Retention time of ODF in sinker: ~1 min

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Example 5. Manufacture of Parallel Coating Film-Type Smokeless TobaccoIncluding Nicotine-Containing Film and Flavor and Functional FoodComposition-Containing Film

First Preparation Tank—Preparing Smokeless Tobacco CompositionContaining Main Components

In the same manner as in Example 1, the plasticizer, the surfactant, thesweeting agent, and the diluent were added into the purified water, andstirred to be dissolved or dispersed, and then the solution washomogenized using the homogenizer (PL-HMZ30DN Poong Lim Tech).

The nicotine oil and the hydroxypropylmethylcellulose as the binder wereapplied and added to the solution in the weight ratio (w/w), and thenthe solution was homogenized again using the same homogenizer.

Second Preparation Tank—Preparing Composition Containing Flavor,Coloring Agent, and Functional Food Composition

In the same manner as in Example 1, the plasticizer, the surfactant, theflavor, the coloring agent, the sweeting agent, and the diluent wereadded into the purified water, and stirred to be dissolved or dispersed,and then the solution was homogenized using the homogenizer (PL-HMZ30DNPoong Lim Tech). The functional food composition and thehydroxypropylmethylcellulose as the binder were applied and added to thesolution in the weight ratio (w/w), and then the solution washomogenized again using the same homogenizer. Red ginseng extract oil(60 brix based on a solid content) having immunity enhancing,anti-cancer, and anti-pneumonia effects, bellflower extract oil (60 brixbased on the solid content) having phlegm loosening, blood sugarlowering, and cholesterol lowering effects, or vitamin C was used as thefunctional food composition.

Gas in the film preparation solution was removed under the vacuumcondition. When the single dose of the nicotine oil is 0.5 mg, the firstregion and the second region were coated in parallel on the pouch withthe casting machine such that each of the first region and the secondregion has a size of 22 mm in width and 14 mm in length and a thicknessof about 91 μm. Thereafter, the first region and the second region weredried for 10 to 20 minutes at the temperature in the range from 50 to90° C. to manufacture the film-type smokeless tobacco containing thenicotine.

Moldability, acceptability, and disintegration degree of the film-typesmokeless tobacco manufactured as described above were identified. Table5 shows moldability, acceptability, and a disintegration time based oncomponents and contents of each Example 5.

TABLE 5 Example 5-1 5-2 5-3 Mixing Component First Second First SecondFirst Second Purpose Name Unit Region Region Region Region Region RegionMain Nicotine Oil mg 0.5 — 0.5 — 0.5 — Component Binder HydroxyPropy- %20 20 40 40 60 60 MethylCellulose Plasticizer Plasticizer % 2.9 2.6 2.92.6 2.9 2.6 Surfactant Surfactant % 4.4 4.0 4.4 4.0 4.4 4.0 SweetingSweeting % 20 20 20 20 20 20 agent agent functional food fucntional food% — Red — Bellflower — Vitamin 12 Composition & Flavor Ginseng 12 &Flavor 12 Flavor 3 Flavor 3 Flavor 3 Coloring Coloring % — 1.0 — 1.0 —1.0 agent agent Supplementary Diluent

Material Solvent Water 100 mg Film Filming Good Good Good Good Good GoodFormation Degree Taste Test Effect of 4 4 4 4 4 4 taste maskingDisintegration Disintegration 3 3 3 3 3 3 Time time(sec) * taste maskingvalue: 1—poor Retention time of Bitter, burning effects: 61 min~ 2—notgood Retention time of Bitter, burning effects: 21~60 min 3—not badRetention time of Bitter, burning effects: 6~20 min 4—excellentRetention time of Bitter, burning effects: ~5 min * Disintegration time:This test is performed using Disintegration tester 1—poor Retention timeof ODF in sinker: 11 min~ 2—not good Retention time of ODF in sinker:6~10 min 3—not bad Retention time of ODF in sinker: 2~5 min 4—excellentRetention time of ODF in sinker: ~1 min

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Example 6. Disintegration Degree and Nicotine Elution Degree ofFilm-Type Smokeless Tobacco Based on Nicotine Content

Disintegration degrees and nicotine elution degrees of Comparativeexample 1-1 (the Niquitin 2.5 mg (a G S K product)), Example 3-5 (afilm-type smokeless tobacco containing 0.5 mg of the nicotine), Example3-8 (a film-type smokeless tobacco containing 0.3 mg of the nicotine),and Example 4-3 (a parallel coating film-type smokeless tobacco of thenicotine 0.5 mg+a flavor film) are compared to each other and shown inTable 6, Table 7, and FIG. 4. In this connection, a disintegrationexperiment was performed using a disintegration tester of InternationalEngineering Co., and a result thereof was shown in Table 6. Table 7 andFIG. 4 show a result of a test of nicotine elution by time under a pH6.8 condition.

TABLE 6 Evaluation Item Comparative Example 1-1 (Niquitin:NicotineExample Example Example 0.5 mg) 3-5 3-8 4-3 Disintegration Equal to or64 ± 6 60 ± 3 70 ± 4 (Water) sec Higher than 600 Disintegration 127 ± 1581 ± 5 63 ± 4 78 ± 5 (pH 6.8) sec

TABLE 7 Comparative Example 1-1 (Niquitin:Nicotine Example ExampleExample Minute 2.5 mg) 3-5 3-8 4-3 0 0 0 0 0 5 81.9 85 88.7 80 10 80.986.7 86.2 81.5 15 81.4 87.1 87.5 85.7 30 80.6 86.8 86.1 90.5 45 79.488.1 36.9 92.4

From the above description, those skilled in the art to which thepresent disclosure belongs will understand that the present disclosuremay be implemented in other specific forms without changing thetechnical idea or essential features. In this regard, it should beunderstood that the embodiments described above are illustrative in allrespects and are not limiting. The scope of the present disclosureshould be construed as including the meaning and scope of the claims tobe described later rather than the detailed description, and all changesor modified forms derived from the equivalent concepts in the scope ofthe present disclosure.

REFERENCE NUMERALS

1, 10: smokeless tobacco 12: first region 14: second region 22: lowerpackaging material 24: upper packaging 26: adhesive material

What is claimed is:
 1. A composition for smokeless tobacco, thecomposition containing: a nicotine activator of 0.01 to 4 parts byweight; a binder of 40 to 80 parts by weight; and a plasticizer of 2 to10 parts by weight.
 2. The composition of claim 1, wherein the nicotineactivator is nicotine oil and has a purity equal to or above 99%.
 3. Thecomposition of claim 1, wherein the binder ishydroxypropylmethylcellulose or hydroxypropylcellulose.
 4. Thecomposition of claim 1, wherein the binder is contained in 40 to 60parts by weight.
 5. The composition of claim 1, further containing wateras a solvent.
 6. The composition of claim 1, wherein viscosity is15,000±5,000 cps.
 7. The composition of claim 1, further containing: aflavor; and at least one of a surfactant, a sweeting agent, and acoloring agent.
 8. A smokeless tobacco comprising: a first region formedby coating the composition for the smokeless tobacco of claim 1 in afilm form, wherein the smokeless tobacco is in an orally dissolvablefilm-type.
 9. The smokeless tobacco of claim 8, further comprising: asecond region formed by coating a flavor composition, a functional foodcomposition, a beauty treatment composition, a pharmaceuticalcomposition, or a mixture thereof in the film form to be adjacent to thefirst region.
 10. The smokeless tobacco of claim 8, wherein at least oneof the composition for the smokeless tobacco, the flavor composition,the functional food composition, the beauty treatment composition, thepharmaceutical composition, and the mixture thereof further contains acoloring agent.
 11. The smokeless tobacco of claim 8, wherein thesmokeless tobacco is disintegrated within 5 minutes after being placedin an oral cavity.
 12. A method for manufacturing orally dissolvablefilm-type smokeless tobacco, the method comprising: discharging thecomposition for the smokeless tobacco of claim 1 in a single dosethrough a first nozzle such that the discharged composition is coated ona first region of a packaging material, thereby forming a first regioncoating; discharging a flavor composition, a functional foodcomposition, a beauty treatment composition, a pharmaceuticalcomposition, or a mixture thereof in a single dose through a secondnozzle such that the discharged composition is coated on a second regionof the packaging material adjacent to the first region, thereby forminga second region coating; and drying the first region coating and thesecond region coating.
 13. The method of claim 12, wherein the drying ofthe first region and the second region is performed at a temperature ina range from 50 to 90° C.